单细胞开放染色质数据分析 | scATAC-seq

终于要开始分析scATAC-seq数据了，联合scRNA-seq就可以做multi-omics，可以深入挖掘TF的调控机制。

基本教程：

• scATAC-seq建库原理，质控方法和新R包Signac的使用

分析工具：

signac - https://github.com/timoast/signac

• QC
• PCA and UMAP
• peak to gene
• integration with scRNA-seq
• DE Peaks
• CoveragePlot
• TF footprinting

TF转录因子高级分析

Transcription factors
General and specific transcription factors. Transcription initiation complex & looping. Combinatorial regulation.

待续~

标签：signac,seq,Transcription,染色质,TF,scATAC,scRNA
来源： https://www.cnblogs.com/leezx/p/16546704.html