Clues to the aetiological heterogeneity of testicular seminomas and non-seminomas: time trends and age-period-cohort effects

Int J Epidemiol. 2000

Background: Most previous epidemiological studies have treated testicular cancer as a single entity. However, some investigators suggest that testicular seminomas and non-seminomas may have different risk profiles. We examine the time trends in incidence of the two main histological types separately.

背景:大多数以前的流行病学研究将睾丸癌作为一个单一的实体进行治疗。然而，一些研究者认为睾丸精原细胞瘤和非精原细胞瘤可能有不同的风险特征。我们分别检查了两种主要组织学类型的发病率的时间趋势。

Methods: From 1970 through 1995, 7296 cases of testicular cancer were registered in the Canadian provinces of Ontario, Saskatchewan and British Columbia. In addition to analyses of the secular trends by age group and birth cohort, an age-period-cohort (APC) model with standard Poisson assumptions was fitted to the data to assess the time effects.

方法:从1970年到1995年，在加拿大安大略省、萨斯喀彻温省和不列颠哥伦比亚省登记了7296例睾丸癌。除了按年龄组和出生队列分析长期趋势外，我们还对数据进行了年龄-时期-队列(APC)模型的标准泊松假设，以评估时间效应。

Results: The age-adjusted incidence rate for seminomas increased by 53%, from 1.5 per 100 000 males in 1970-1971 to 2.3 per 100 000 males in 1994-1995. Non-seminomas increased by 91%, from 1.1 to 2.1 per 100 000 males over the same period. Non-seminomas were more frequent at young ages whereas seminomas dominated in older ages. In contrast to seminomas, non-seminomas occurred predominantly among adolescent men (15-19 years), with a fourfold increase between 1970-1971 and 1994-1995. Age-period-cohort modelling showed that the increase in the risk of both seminomas and non-seminomas followed a birth cohort pattern, but with differences in birth cohorts in addition to significantly distinct age patterns.

结果:精原细胞瘤的年龄调整发病率增加了53%，从1970-1971年的1.5 / 10万男性增加到1994-1995年的2.3 / 10万男性。同期，非精原细胞瘤增加了91%，从每10万名男性1.1例增加到2.1例。非精原细胞瘤在年轻时更常见，而精原细胞瘤在老年时占主导地位。与精原细胞瘤相反，非精原细胞瘤主要发生在青少年男性(15-19岁)，1970-1971年至1994-1995年期间增加了4倍。年龄-时期-队列模型显示，精原细胞瘤和非精原细胞瘤的风险增加均遵循出生队列模式，但除了明显不同的年龄模式外，出生队列也存在差异。

Conclusions: Our findings support the hypothesis postulating aetiological heterogeneity in the development of seminomas and non-seminomas. We suggest that epidemiological studies of testicular cancer treat seminomas and non-seminomas separately.

结论:我们的研究结果支持了精原细胞瘤和非精原细胞瘤发病的异质性假设。我们建议睾丸癌的流行病学研究应分别治疗精原细胞瘤和非精原细胞瘤。

标签：精原细胞,non,1995,读书笔记,1970,seminomas,testicular,APC,2.1
来源： https://blog.csdn.net/weixin_42259543/article/details/113484734