CNS、ENS和PNS的发育过程

• central nervous system (CNS)
• peripheral nervous system (PNS)
• enteric nervous system (ENS)

做这部分的科研必须要把这个问题搞得一清二楚，当前到底研究到什么地步了？

从胚胎发育的起源到成熟个体大脑中各种subtype的细胞类型的作用。

 

分清两个发育过程：

• 生命发育，就是个体的其他器官的发育
• 智能发育，特指神经系统地发育

The single-cell transcriptional landscape of mammalian organogenesis - introduction

• The implantation of the blastocyst on embryonic day (E) 4.0 is followed by gastrulation and the formation of germ layers on E6.5–E7.51,2 .
• At the early-somite stages, the embryo transits from gastrulation to early organogenesis, forming the neural plate and heart tube (E8.0–E8.5).
• In the ensuing days (E9.5–E13.5), the embryo expands from hundreds-of-thousands to over ten million cells, and concurrently develops nearly all major organ systems.
• Unsurprisingly, these four days have been intensively studied. Indeed, most genes that underlie major developmental defects can be studied in this window3,4.

 

首先，看一下成熟的人和老鼠体内的神经系统是什么样的；

Nervous System - 粗略大概

Nervous System - 3D

 

其次，每部分的神经系统里面各有哪些subtype的神经细胞； 

Neuronal subtype specification in the cerebral cortex

Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain

Neuronal subtype specification in establishing mammalian neocortical circuits

 

最后，这些神经细胞是如何一步一步从受精卵发育而来的；

这就是我要做的工作

 

Development of the Nervous System - 在线阅读，看书是学习最快的方法

另附一门课程：Medical Neuroscience

 

相关数据库：

Molecular Architecture of the Mouse Nervous System - p19-p23, 8w

The single-cell transcriptional landscape of mammalian organogenesis - 部分数据可用

 

待续~

标签：发育,CNS,Nervous,PNS,System,system,subtype,ENS,nervous
来源： https://www.cnblogs.com/leezx/p/11196200.html