文献复现 | The support of human genetic evidence for approved drug indications
作者：互联网
文献复现是非常重要的技能，能迅速模仿顶尖的研究也是不错的能力，中二的叫法就是“写轮眼”。
核心：
- 熟悉数据
- 大致知道基本的算法
- 知道分析核心的目的
复现第一篇：
The support of human genetic evidence for approved drug indications - NG
核心：一个卡方检验，所有的gene可以分为四类。
| genetic evidence | None | |
| FDA approval | ||
| None |
指导意义：以后你找target，就优先去找有genetic evidence的gene，这样成功的概率更高。
知识点checkpoint：
- preclinical and clinical phases to launched drugs【一个药物获得FDA批准的大致流程】
- GWASdb（已关闭）和GWAS Catalog的数据类型，就是GWAS的lead SNP，每一行数据就是一个association
- Medical Subject Heading (MeSH) terms - treeView
数据：
- In the final data set, we had 18,566 genetic associations to 434 MeSH traits that mapped to 6,120 genes outside of the extended major histocompatibility complex (xMHC), with a total of 13,855 gene-trait combinations.
- Genes involved in rare, mendelian traits were derived from Online Mendelian Inheritance in Man (OMIM), providing a data set with 1,898 genes annotated to affect 2,145 traits with MeSH terms, for a total of 2,627 gene-trait combinations.
- 22,270 drugs known to modulate 1,824 human non-xMHC drug targets for 705 indications, giving a total of 19,085 target-indication pairs
附件数据：
标签：indications,support,drug,evidence,traits,genetic,human,gene 来源： https://www.cnblogs.com/leezx/p/15377266.html